/Parent 2 0 R Publication Team The drug is already FDA-approved in the US to be used on humans, especially for those who undergo organ transplants. For this project, the lab aims to learn how to slow down aging or increase the longevity of different species of dogs. The Dog Aging Project team is actively recruiting 50 companion dogs for their future studies. 5 0 obj /Image28 48 0 R /F5 19 0 R endobj /Type /Pages /G10 11 0 R /StructParents 0 Working together, we just might be able to help your dog live a longer, happier life. /Image47 57 0 R /Contents [68 0 R 69 0 R] /Footer /Sect 3 0 obj >> 130 0 R 131 0 R 132 0 R 133 0 R 134 0 R 135 0 R 136 0 R 137 0 R 138 0 R 139 0 R /ParentTree 8 0 R Scientists have been working for decades to find interventions to at least delay age-related illnesses, as well as promote longevity. Now, they and Creevy are tracking how dogs’ health changes over their lifespans, as well as testing a promising anti-aging drug. %���� The Dog Aging Project is a long-term biological study of aging in dogs, centered at the University of Washington. The study has two parts: the longitudinal study of aging in pet dogs and rapamycin intervention trial in pet dogs. /Footnote /Note Publication /K [9 0 R] stream As noted here by the Life Extension Advocacy Foundation, the Dog Aging Project researchers are moving ahead with a large study of companion animals. /GS5 44 0 R Researcher Matt Kaeberlein is spearheading a project to test the drug rapamycin’s effects on boosting longevity in dogs. They also live in a human environment with comparable health care, risks, and the chances of getting sick when they get older. 166 0 R 167 0 R 168 0 R 169 0 R 170 0 R 171 0 R 172 0 R 208 0 R 209 0 R 175 0 R /StructParents 0 Rapamycin and Dogs. << /StructTreeRoot 3 0 R Kaeberlein said, “It’s complete speculation, but with something like rapamycin, we might get 10 to 15, maybe as much as 20 years. /Image30 49 0 R /ca 1 Popularly known under its trade name Rapamune, the drug is used to prevent rejection of an organ transplant. /Textbox /Sect Bold Business is a proud part of Bold Business Group, an integrated publications, media, technology, solutions, advisory and investment group. A secondary purpose is to determine whether rapamycin improves various measures of health in aging dogs. The Dog Aging Project, a national research effort to learn how to foster healthy longevity in canines is looking … /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] /RoleMap 7 0 R /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] It works with various researchers, veterinarians, and even dog owners as well. As opposed to other model organisms used to study aging, dogs share the human environment, are subject to similar risk factors, receive comparable medical care, and develop many of the same age-related diseases humans do. We use cookies to improve our website experience. /Length 4601 /Annots [65 0 R 66 0 R 67 0 R] endobj �+Sl�V����˗���Gޗ"���%{O���ȇ�,Ej籬s�/�rF �}S��t���6�Z����;[�� /X9 14 0 R According to Kaeberlein, the lifespan of dogs is close to that of humans, only seven times faster. 140 0 R 141 0 R 142 0 R 143 0 R 144 0 R 145 0 R 146 0 R 147 0 R 148 0 R 149 0 R /F6 20 0 R /Chartsheet /Part In this project, the lab hopes to understand the role genetic factors and environmental factors play in health and longevity. >> /Kids [5 0 R 6 0 R] /Image43 55 0 R The Dog Aging Project is an innovative initiative that brings together a. community of dogs, owners, veterinarians, researchers, and volunteers to carry. %PDF-1.5 /ParentTreeNextKey 3 “It started to function better. /Workbook /Document Rapamycin for dogs -- Here's how to get rapamycin for your dog. >> endobj >> /Type /XObject The study concluded that rapamycin for dogs improved heart condition and potency. Therefore, the organ is able to function well. /Annotation /Sect << The Dog Aging Project: Rapamycin as a Potential Aging Modulator in Dogs • Indicators of immune function modulation: • EOS (P=0.015) and LYM (P=0.01) decreased, WBC and PMN did not. /K [70 0 R 71 0 R 72 0 R 198 0 R 85 0 R 199 0 R 103 0 R 104 0 R 200 0 R 112 0 R One is a true observational longitudinal study of aging, and the other is TRIAD, and most of the time so far has … x��yp��}�h i�f&i2�2S�4d�IҤM�I�v��1M�6�N2iC�M�dhJ��Ʒ�|��`cc|b�ԧ$�>�u�CƦHZ�m�p��:˫Z��~�Ϯ���}w�w?�~��_�R Ѕ7����������f���������R�:f���z����\i�t�*\�n��]߸�Kw�7�Q63�p�:r�d�����k�-�U����t���!�z��1�l�k�k��͍h�mlm=�N���.l��6�k��j���ce�p��p�� ? /ModDate (D:20160617135533-07'00') /F3 61 0 R He is currently investigating many of these questions through the Dog Aging Project and the compound rapamycin—the only known pharmacological agent to extend lifespan all the way from yeast to mammals—across a billion years of evolution. Participating dogs will be given heart ultrasounds and have their blood pressure monitored at one of … 1 0 obj << Writers and Contributors 90 0 R 91 0 R 92 0 R 93 0 R 94 0 R 95 0 R 96 0 R 97 0 R 98 0 R 99 0 R �^#�O1X��|�b[}[��� ����u�+oc[˹�v����)��V^v�����h��sFJyk��t��K� �-�� ��)&mG��[��Z� JP /Diagram /Figure /Artifact /Sect https://consumer.healthday.com/senior-citizen-information-31/longevity-982/can-fido-fetch-the-fountain-of-youth-733876.html, https://edition.cnn.com/2016/10/06/health/rapamycin-dog-live-longer/index.html, http://geroscience.com/pet-dogs-rapamycin/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411365/, Publisher’s Note /Image41 54 0 R >> He and his team recruited 40 middle-aged companion dogs around Seattle. Typically, the body’s initial reaction is to treat the new organ as an alien, considering it a bacteria or virus. << TriviumVet have developed a novel Rapamycin formulation for … /Subtype /Image << In this study, 24 middle-aged healthy dogs received either placebo or a non-immunosuppressive dose of rapamycin for 10 weeks. /Resources << /Marked true The Dog Aging Project's rapamycin trial will test the effects of the drug on subjects' cognitive function, heart function, immunity and cancer incidence. Although the media attention has been focused on the rapamycin component of the project, Kaeberlein is equally excited about the longitudinal study of aging. /X12 15 0 R By Gary Greenberg. 120 0 R 121 0 R 122 0 R 123 0 R 124 0 R 125 0 R 126 0 R 127 0 R 128 0 R 129 0 R >> /Endnote /Note << /F1 59 0 R /Macrosheet /Part If all goes well for Kaeberlein’s dogs, concerns over safety may not hound rapamycin for too much longer. UW Medicine. endobj >> /Type /Catalog endobj endobj << endobj By closing this banner or continuing to use BoldBusiness.com, you agree to our practices. This study, being conducted as part of the larger Dog Aging Project research efforts, investigates the use of Rapamycin to potentially slow the ageing process and prolong healthy life.
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